Promethazine HCl and Codeine Phosphate Oral Answer really should be utilized with caution in individuals with extreme impairment of renal function, and people needs to be monitored intently for respiratory depression, sedation, and hypotension.

This medication has become prescribed in your present ailment only. Tend not to use it later on for another issue unless explained to to do so by your physician. A different medication could be necessary in All those instances.

Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Answer shouldn't be increased if cough fails to reply; an unresponsive cough need to be reevaluated in 5 days or sooner for doable underlying pathology, for instance foreign overall body or reduced respiratory tract ailment [see Dosage and Administration (two.3)].

Indicators and indications of overdosage with promethazine HCl range between gentle despair from the central anxious program and cardiovascular technique to profound hypotension, respiratory despair, unconsciousness, and sudden Demise.

Codeine has reduced plasma protein binding with about seven to twenty five% of codeine bound to plasma proteins. Codeine passes the blood brain barrier and also the placental barrier. Tiny amounts of codeine and its metabolite, morphine, are transferred to human breast milk.

An increased chance of certain malformations with codeine publicity for instance respiratory malformations, spina bifida and congenital heart defects ended up claimed in some scientific studies.

In animal replica scientific studies, codeine administered with the oral path to pregnant rats throughout the period of organogenesis improved resorptions and reduced fetal weights at a dose roughly 25 situations the most encouraged human dose (MRHD) from the existence of maternal toxicity (see Knowledge).

A Health care Skilled needs to be consulted prior to using any drug, transforming any diet or commencing or discontinuing any training course of remedy.

Bluish lips or skin chills clay-colored stools cold sweats confusion cough dark urine minimize within the frequency of urination minimize within the urine volume diarrhea hard or troubled breathing difficulty in passing urine (dribbling) dizziness dizziness, faintness, or lightheadedness when getting up from lying or sitting down place quick, pounding, or irregular heartbeat or pulse sensation of warmth fever headache high fever hives or welts, itching, or rash enhanced sweating irregular, fast or slow, or shallow respiration massive, hive-like swelling around the facial area, eyelids, lips, tongue, throat, arms, legs, ft, or intercourse organs loss of appetite loss of bladder Management nausea noisy respiration not respiration agonizing urination pale or blue lips, fingernails, or skin rectal bleeding redness of the confront, neck, arms, and occasionally, higher upper body redness on the skin seeing, Listening to, or feeling factors that aren't there seizures severe muscle mass stiffness shakiness during the legs, arms, or arms abdomen suffering sweating tightness while in the upper body tiredness trembling or shaking of your hands or feet uncomfortable breath odor abnormal tiredness or weakness unusually pale skin vomiting of blood yellow eyes or pores and skin Get emergency assistance quickly if any of the subsequent indicators of overdose occur:

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Get this medication accurately as prescribed to reduce the potential risk of addiction. Check with your health care provider or pharmacist For additional particulars.

Tend not to flush medications down the toilet or pour them right into a drain unless instructed to do so. Correctly discard this solution when it really is expired or no longer desired. Consult your pharmacist or neighborhood waste disposal firm.

This drugs could be useful for other needs; Promethazine codeine syrup talk to your wellness care provider or pharmacist Should you have concerns.

Offering or giving freely Promethazine Hydrochloride and Codeine Phosphate Oral Solution may possibly hurt Some others, which is from the law. Tell your healthcare company For those who have at any time abused or been dependent on Liquor, prescription medicines or Road medicines.